VB .NET - Como Criar Banco de Dados em Tempo de Execução

Public Class Form1

    Private Const CONNECTION_STRING = "Provider=Microsoft.ACE.OLEDB.12.0;Data Source=C:\BD\Cadastro.accdb"

    Private Sub Button1_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Button1.Click

        Dim catalogo As New ADOX.Catalog

        Try

            catalogo.Create(CONNECTION_STRING)

            MessageBox.Show("Banco criado com sucesso!")

        Catch ex As Exception

        End Try

    End Sub

    Private Sub Button2_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Button2.Click

        Dim conn As New OleDb.OleDbConnection(CONNECTION_STRING)

        Dim cmd As New OleDb.OleDbCommand("CREATE TABLE Contato (ID int not null, Nome varchar(50))", conn)

        conn.Open()

        cmd.ExecuteNonQuery()

        MessageBox.Show("Tabela 'Contato' criada com sucesso!")

    End Sub

    Private Sub Button3_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Button3.Click

        Dim conn As New OleDb.OleDbConnection(CONNECTION_STRING)

        Dim cmd As New OleDb.OleDbCommand()

        cmd.Connection = conn

        cmd.CommandType = CommandType.Text

        conn.Open()

        cmd.CommandText = "INSERT INTO Contato VALUES (1, 'Contato 1')"

        cmd.ExecuteNonQuery()

        cmd.CommandText = "INSERT INTO Contato VALUES (2, 'Contato 2')"

        cmd.ExecuteNonQuery()

        cmd.CommandText = "INSERT INTO Contato VALUES (3, 'Contato 3')"

        cmd.ExecuteNonQuery()

        MessageBox.Show("Registros inseridos com sucesso!")

    End Sub

End Class

 Espero ter ajudado e até mais!!!